Doom, a product of the Drosophila mod(mdg4) gene, induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins
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منابع مشابه
Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death
Apoptotic cell death is a mechanism by which organisms eliminate superfluous or harmful cells. Expression of the cell death regulatory protein REAPER (RPR) in the developing Drosophila eye results in a small eye owing to excess cell death. We show that mutations in thread (th) are dominant enhancers of RPR-induced cell death and that th encodes a protein homologous to baculovirus inhibitors of ...
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15 صفحه اولInhibitor of apoptosis proteins and apoptosis.
Apoptosis is a physiological cell death process that plays a critical role in development, homeostasis, and immune defense of multicellular animals. Inhibitor of apoptosis proteins (IAPs) constitute a family of proteins that possess between one and three baculovirus IAP repeats. Some of them also have a really interesting new gene finger domain, and can prevent cell death by binding and inhibit...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1997
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.17.5.2835